Leptin Resistance is the one of the reasons why so many overweight people have trouble losing weight. African Mango can help correct Leptin Resistance.
Leptin is a hormone produced by Adipocytes (similar to fat cells) and it has two major roles within the human body. Leptin binds to your hypothalamus, a part of the brain that controls hunger, and sends signals to the rest of the body to stop eating when you are full. Its second role is to help the body use stored fat as energy.
Given that leptin reduces appetite and burns fat, you would think that the key to weight loss would be increased leptin levels but studies have found that overweight people tend to have higher leptin levels than people of average weight. The problem? Overweight people tend to have leptin resistance. The more a person eats, the more leptin the brain produces to tell the person to stop eating. This overloads the receptors in the brain and on the fat cells themselves. Once the receptors are overloaded, you become Leptin Resistant, and stop responding to the leptin. Once you become Leptin Resistant, your fat cells start to get larger, your ability to burn fat decreases, your hunger remains and your weight increases.
Researchers have found that people with Leptin Resistance have high levels of C-reactive protein or CRP. Too much CRP in the body is a bad thing and is major factor contributing to Leptin Resistance. Studies have shown that African Mango Seed extract can decrease CRP levels by 52% over 10 weeks. That drop in CRP makes the body more responsive to leptin. Increased response to leptin means you feel full faster and your body burns fat more easily.
African Mango helps correct Leptin Resistance but that’s not all it can do. Studies have shown that African Mango can increase body levels of adiponectin, a hormone that has been shown to have anti-inflammatory and positive weight loss effects. African Mango is also believed to inhibit amylase production. Inhibited amylase production causes the body to take longer to convert carbohydrates into simple sugars. This leads to improved insulin levels and a lower glycemic index. Finally, African Mango has also been shown to help inhibit the production of glycerol-3-phosphate dehydrogenase, an enzyme that helps convert sugar to stored fat. All of these factors help African Mango contribute to healthy weight loss.